Endocrine Abstracts

Somatotroph adenomas are characterized by growth hormone hypersecretion and cell proliferation. We have previously identified crosstalk between the cAMP pathway and the MAPKinases ERK1/2 cascade and shown the central place of the MAPKinases in the control of the pituitary function in GH4C1 somatolactotroph cell line.The spatio-temporal organization of the signalling partners governs signalling fidelity and encodes the specificity of biological responses....

Objective: Primary aldosteronism (PA) is the first cause of endocrine hypertension accounting for about 6% of all cases of hypertension. According to international guidelines, PA screening is based on plasma aldosterone-to-renin concentration ratio (ARR) computation. Nevertheless, measurement of urine aldosterone excretion may be of interest since it integrates aldosterone secretion over 24 hours. However, available urine aldosterone immuno-assays have poor specificity.<p ...

Pituitary tumors are most usual intracranial tumors, displaying hormonal hyper-secretion with in some cases a sustained cell proliferation. The somatotroph adenomas are characterised by a GH hypersecretion. The current treatments are based on somatostatinergic or dopaminergic agonists. Unfortunately, there is steel 50% of patients, which remain insensitive to these treatments. The aim of our work is to find a pharmacological alternative to treat the patients resistant to the c...

Background: Hypercalciuria is frequent in patients with acromegaly, but it is unclear how GH/insulin-like growth factor 1 (IGF1) regulate renal calcium handling. Elevated fasting plasma calcium levels despite increased glomerular filtration suggest enhanced renal calcium reabsorption.Objective: To investigate the impact of acromegaly on phosphocalcium metabolism.Design: Prospective sequential study (ClinicalTrials.gov Identifier: N...

Introduction: Persistent primary hyperparathyroidism (pHPT) occurs in 2.5 to 15% of cases after parathyroidectomy. Pre-operative localization studies (usually 99mTc-MIBI and cervical ultrasonography (US)) allow focused surgical approach (unilateral neck exploration or minimally invasive parathyroidectomy). Few studies have evaluated the best pre-reoperative approaches in case of persistent sporadic pHPT. The aim of our study is to evaluate the value of a second pre-...

Background: X-linked hypophosphatemia (XLH) is a rachitic disorder characterized by renal tubular phosphate wasting resulting from increased circulating activity of the fibroblast growth factor FGF23. Secondary and tertiary hyperparathyroidism have been reported in XLH patients in small retrospective studies, however this complication has never been systematically evaluated in a large cohort.Aim of the study: To compare parathyroid function of adult XLH ...

Somatostatin analogs (SSAs) such as octreotide (OCT) are currently effective in controlling most hypersecretion associated symptoms of Gastoenteropancreatic-neuroendocrinetumors (GEP-NETs). The results of the phase IIIb PROMID trial showed that OCT doubled time to progression for patients with metastatic neuroendocrine midgut tumors compared with placebo. SSAs act on different intracellular pathways through different somatostatin receptor (Sst) subtypes. While OCT is mainly an...

Introduction: Health-related Quality of Life (HR-QoL) is usually impaired in patients with thyroid diseases compared to the general population. Thyroidectomy is largely performed in case of benign thyroid disease, and can be associated with severe long-term complications: vocal cord palsy (VCP), hypoparathyroidism. Our goal was to report the long-term HR-QoL outcomes after thyroidectomy using the MOS 36-item short form health survey (SF-36) self-questionnaire.<p class="abs...

Objective: Adrenal venous sampling (AVS) is the gold standard method to assess lateralization of aldosterone secretion in patients with primary aldosteronism (PA). The selectivity index (SIcortisol, the adrenal to peripheral vein ratio of cortisol concentrations) determines correct catheter positioning during AVS. The lateralization index (LIcortisol, the aldosterone to cortisol ratios between adrenal veins) distinguishes unilateral aldosterone producing ...

NC-CAH is diagnosed in pubertal/post-pubertal women because of androgen excess however, the risk of potential adrenal insufficiency is not known, and indication of systematic glucocorticoid replacement therapy is controversial.Design: Prospective controlled clinical study in a tertiary referral center. 20 women with NC-CAH (serum stimulated 17-OHP >10 ng/ml/250 μg, Synacthen) comparatively to matched healthy women, were included if they had not ...